APCcdh¹ activity in mouse oocytes prevents entry into the first meiotic division

Title: APCcdh¹ activity in mouse oocytes prevents entry into the first meiotic division
Creator: Reis, Alexandra; Chang, Heng-Yu; Levasseur, Mark; Jones, Keith T.
Relation: Nature Cell Biology Vol. 8, Issue 5, p. 539-540
Publisher Link: http://dx.doi.org/10.1038/ncb1406
Publisher: Nature Publishing Group
Resource Type: journal article
Date: 2006
Description: Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh¹ is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh¹ is active in mouse oocytes and is necessary to maintain prophase arrest.
Subject: APCcdh¹; mouse; mammalian; cyclin; meiotic; oocytes
Identifier: uon:6563
Identifier: http://hdl.handle.net/1959.13/804244
Identifier: ISSN:1465-7392
Language: eng
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